Structure based drug design is a powerful method especially when used as a tool within an armamentarium for discovering new drug leads against important targets after a target and a structure of that target are chosen new leads can be designed from chemical principles or chosen from a subset of small molecules that scored well when docked in silico against the target after a preliminary . Structure based design is important not only in attaining the goal of discovering drugs that progress to the clinic and regulatory approval for patient benefit but also in the search for potent selective and cell permeant chemical probes that can be used with confidence to explore the mechanistic biology of healthy and diseased cells alongside genetic approaches such as rna interference and
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